منابع مشابه
The effect of progressive aerobic continuous training on angiotensin-1, angiotensin-2 and angiotensin-converting enzyme type 2 in patients with heart failure
Background: Chronic hypertension causes structural and functional changes in the heart, ultimately leading to heart failure (HF), which further increases mortality and morbidit. HF is a complex clinical syndrome caused by various structural or functional abnormalities of the heart that impair the filling capacity of the ventricles. The findings of various trials have shown the association betwe...
متن کاملBrain Renin–Angiotensin System in Hypertension, Cardiac Hypertrophy, and Heart Failure
Brain renin-angiotensin system (RAS) is significantly involved in the roles of the endocrine RAS in cardiovascular regulation. Our studies indicate that the brain RAS participates in the development of cardiac hypertrophy and fibrosis through sympathetic activation. Inhibition of sympathetic hyperactivity after myocardial infarction through suppression of the brain RAS appears beneficial. Furth...
متن کاملBrain angiotensin and heart failure: further evidence for a critical role of mitogen-activated protein kinases.
In both humans and animals, heart failure is associated with sympathoexcitation and increased activity of the renin–angiotensin system.1,2 Studies in animals have shown that in heart failure, there is increased expression of angiotensin type 1 (AT1) receptors in key brain regions regulating sympathetic activity, such as the nucleus of the solitary tract, rostral ventrolateral medulla (RVLM), an...
متن کاملBrain angiotensin-converting enzyme activity and autonomic regulation in heart failure.
Several recent studies suggest an important role for the brain renin-angiotensin system in the pathogenesis of heart failure. Angiotensin-converting enzyme (ACE) activity and binding of angiotensin type 1 (AT1) receptors, which mediate the central effects of ANG II, are increased in heart failure. The present study examined the relationship between brain ACE activity and the autonomic dysregula...
متن کاملHeart failure and the brain: new perspectives.
Despite recent therapeutic advances, the prognosis for patients with heart failure remains dismal. Unchecked neurohumoral excitation is a critical element in the progressive clinical deterioration associated with the heart failure syndrome, and its peripheral manifestations have become the principal targets for intervention. The link between peripheral systems activated in heart failure and the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2008
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.108.119099